Saturday, October 31, 2009

This is the home of my NON-DEATHLESS prose

I originally published this in the ARCADIAN RECORDER on October 31 2009 but it got deleted when I transferred all of that blog's old entries to MO goes PO.
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Arcadian-Recorder-the-blog ( and my Twitter and Facebook offerings) represents just one side of my divided personality: call it my pamphleteer side.

I sit down in front of my laptop and quickly write out whatever grabs my mind at that moment.

Write it, post it and get over it - deathless prose it is not.

I have no intentions of collecting it, revising it and putting it out in a book-of-essays format : ugh !

Its on the net, its worldwide and its free --- which probably accurately describes its current literary market value.

But when I hope to write a novella length narrative that will still be readable, long after I am gone, I turn to a good old fashioned analog paper book that I publish myself.

Call it a mook or a heftroman if you wish (a hybrid magazine-book), to me it is simply an issue of the Arcadian Recorder journal that looks and feels like a small book.

But an environmentally 'green' book with no wasted dead trees allocated to useless padding.

With nice book paper and a nice cover stock paper - and bound so it stays open and easy to read.

And I want to illustrate it, and have the fun of printing it and binding it myself.

Call it my creative side coming to the fore.

No, novella doesn't mean it is fictional - and don't call it non-fictional either.

Italians will remind you that novella - or novel for that matter - is just what it sounds like - novel,novelty,news - which sounds pretty 'fact-oriented' to me.

Today, novella should just mean a prose work that is too long for a newspaper, magazine or journal, but is too short to stand alone in a conventional book publishing offering.

I would say anything that is from 17,500 to 35,000 words in total, (unpadded).

Conventional book publishers may need at least 190 pages to get bookstores and readers to warm to it --- that can be less than 35,000 words --- but it must still be padded out some how to that length in pages to get a fair hearing.

Dead trees falling needlessly.

Myself, and a lot of others, think that these short-read/low weight/low priced books (80 pages in an A-6 size) have a lot of legs in the new book economy.

And a handful of them can be bundled and themed into a big fat book ,if the conventional book publishers and book sellers think they can sell big numbers in a few months - the route that they regard as the only viable book business model today.

Instead, my books will be printed on my home computer and home laser printer and be available forever, but only on "demand", as customer cash-in-hand orders come in.

No more pulping tons of unsold/returned for full credit books - sorry - I just don't think its the green thing to do to a green-oriented book series.

My Chebucto Community Net website, marshall.chebucto.net , will have paypal options on it, for customers world wide.

I can mail them world wide at the low cost 50 gram letter post rate - and make money - not much money, but I will make some on each and every sale.

Their price, before their very reasonable mailing costs, will be competitive with other serious literary factual narratives : at about 10 cents per 300 words.

Frugally, I plan to sell the originals of their full color cover art painting (as well as the originals of the black & white paintings that go on the pages inside) on the same website and shipped out the same way.

Tuesday, October 20, 2009

In a crisis, r-selected COPYRIGHT is better than K-selected


Here I go again, "Arguing From Nature!"

I am going to borrow the kernel of a very complicated and subtle theory from biology and apply it , as a metaphor, to a critical issue in human culture.

Metaphors have a habit of climbing away from their Doctors Frank-n-Steins and developing an independent existence of their own, so there is always a danger to this kind of activity.

None the less, let's try out r- and K- for size.

A generation of disinterested Art and Commerce undergraduates have tried to slither through the exams in a scientific subject they didn't really like, by recording the following mnemonic :

K-selected/K-strategists = K-oncentrated

r-selected/r-strategists = r-adiated .

In stable,narrow, niches in ecology, K-selected species are competitively successful by doing only one thing (being rigid in their ways of surviving) but doing it better than anyone else.

They tend to be very large in size and few in number; producing relatively few offspring late in life, which they then tend carefully to maturity.

What energy they do collect they mostly devote to keeping themselves alive and growing bigger than other competitors and then, late in life, they K-oncentrate what little energy they can give to reproduction, towards producing a very few offspring which they nurture to maturity.

Humans are mostly K-selected in our biology - in our culture we are a mixture of K- and r- . We have a choice. More on this later.

Bell Aliant is an typical example of a K-strategy human institution - it has one successful strategy that has worked well for them in the stable niche-period of the Industrialized West during the last 150 years and they are almost biologically- reluctant to change.

Species that are r-selected tend to be extremely small - think of bacteria, other microbes and many rodents and insects.

They flourish best in unstable niches - unstable in conditions and in time. Regard them as Nature's weeds and opportunists. They do many many things, none of them very well -- jacks of all trades.

They are very numerous and reproduce early, releasing (r-adiating) thousands and millions of their offspring widely all over the environment.

In point of truth, they abandon their offspring when they are (a) very small & weak (b) and floating into mostly hostile territories.

It seems to be both cruel and an unsuccessful strategy, in our contemporary /western/ urban/ middle class/ eyes.

But we are the ultimate in K-orientation and we are living, moreover, on borrowed time and space.

Color us ignorant and arrogant.

We fail to realize that throughout most of human existence, let alone for the rest of Life's creatures' existence and and let alone the rest of earth history, the world, in sum, has been more unstable than stable.

Whether as human peasants or as bacteria, r-selected jack-of-all-trades fecundity tends to work better than the alternative, over the long haul and over the enlarged range.

In fact, while your professors of biology will rarely tell you this because their interest is almost always animals or plants, most of life on Earth has always been r-selected, not just in numbers, but in weight of living biomass and in 'space and time'.

By 'time' in the phrase, 'space and time' , I mean that over the roughly four billion years of Life on Earth, the r-selected have always been around while the k-selected have only appeared intermittently and then only stayed for a short time.

The blue green algae we see in every stagnant pool of water are actually bacteria and have been found, as massive fossil collections, in the oldest rocks on earth.

They may be even older - we simply haven't found any older rocks yet.

Found everywhere water pools and collects, around for almost four billion years - as a strategy, r-selection looks pretty good on our blue-green pals.

By 'space' in the phrase ' space and time' , I mean the fact that while K-selected creatures like blue whales,elephants and even humans can only exist (unaided by fossil fuels) in a few small corners of the world, r-selected microbes exist everywhere.

Inside us, for a start, their cells outnumbering ours many fold - though most of "them" are "us", as we would die and cease to be human without our helpful commensal bacteria and their services.

But bacteria exist miles underground, without any sun, living off the chemical energy in minerals - perhaps having unexpectedly profound consequences in the creation of petroleum and natural gas, among other semi-minerals.

They exist high into the atmosphere.

They can flourish on ice at the Poles, and in extremely hot and extremely harsh chemical-waters pouring out of volcanic structures.

Now this is biology, not culture, and may seem to be totally deterministic, beyond all interest to humans who can alter their cultural practices.

But the r-selected amongst us are deterministically flexible - and this seems almost an oxymoron, but is actually the key to their ongoing successful domination of Life on Earth throughout history.

While in stable times, the expert/specialist/professional earns the best incomes, in times of crisis, they flounder while the poor freely adapt and go on surviving.

We see this during every world war, in the worst affected countries.

The problem in a crisis, for the specialist and the K-selected, is that they have intellectual assets that cost them plenty to obtain and of which they are very proud.

The fact that those assets no longer work during the crisis is only half realized and this inertia in adapting is often fatal.

By contrast, bacteria and other small celled creatures have very good mechanisms for correcting errors in reproducing DNA - during stable conditions.

They are thus acting in a strictly K- fashion with regards to their precious intellectual property - in times of stability.

But when their world goes into an unstable crisis, they stop repressing their other built-in repair mechanisms that are extremely careless in reproducing their original DNA.

Strange and wonderful mutations emerge - most are useless or even worse, fatal.

But a few are the way forward to surviving under these troubling new conditions.

Waiiit ! There is more !

They don't hold onto this wonderful news, this Gospel, they radiate it far and wide as Open Source DNA, not demanding copyright royalties from other species and variants of bacteria that take it up.

As my good friend Dr Dawson demonstrated way back in 1930, bacteria, when hit by a crisis, "Unleash Chiang Kai-Shek" in the form of 'cassettes' of DNA encoding a new or underused function and send it out onto the bacterial Internet (the fluids surrounding them) for any species to take up and use.

Generally these different species bacteria not being (by definition) exactly the same as the original bacteria releasing these Open Source Genes, they have to mash up their own DNA to get the Gene to work.

What emerges - to the benefit of the whole of bacteria-dom - is two variants on that gene. One is the original gene, the other is the new mash-up version. Both work well - but under different conditions.

All bacteria-dom benefits under these loose copyright rules.

Lets look at a concrete example : the worldwide bacterial collective response to the billion-fold increase in antibiotic bactericides after 1945.

Antibiotics are natural bactericides, found in nature in terms of hundreds of millions of microgram-sized amounts annually worldwide - widely dispersed in tiny amounts all over, but only lethal to what bacteria had to be extremely close by.

We humans - by giving antibiotics freely to humans and farm animals - upped the annual outpouring into the waters of the world to levels of hundreds of millions of kilograms of antibiotics.

A billion-fold increase - now antibiotics were killing all sorts of bacteria under all sorts of situations.

Bacterial Antibiotic Resistance was how humans saw the resulting response.

Bacteria had worked out ways to ruin the effects of antibiotics eons ago, but they usually leaves the genes that encode for this ability way in the background - very few bacteria have these genes and even fewer among them are using them at any point in time.

It costs precious energy to create these gene products and bacteria are successful above all for being the most frugal creatures on Earth.

They travel lean - devoting all their free energy to reproducing and as little as possible to storing tools, "just in case it needs them".

But in their unstable and crisis-oriented world, they do need those tools - perhaps not minute by minute, but over periods as short as every few weeks.

Their solution is to create a worldwide library of Open Source Genes that aren't needed for basic daily life, but are life-saving on occasion.

A bacteria that daily faces and defeat antibiotics might also daily leak out into the environment the genes that can ruin antibiotics.

Other bacteria that have no need that gene's function, right now, have excellent systems for detecting unwanted DNA - they simply 'eat' the antibiotic-destroying gene rather than incorporating it into their chromosome.

But when antibiotics flood the area, for both types of bacteria, threatening all, the bacteria start up a collective response.

The antibiotic destroying bacteria starts producing more of their gene product and starts leaking more of the gene that produces it, into the environment.

The bacteria without the capability to destroy antibiotics suddenly throttle their foreign DNA check system and start taking up all sorts of foreign DNA into their chromosome, including the antibiotic-destroying gene.

At the micro level ,this process isn't pretty - billions and billions of bacteria die trying to get it right, but eventually some do and flourish and bacteria-dom, as a whole, survives.

Multi-antibiotic Resistance Killed Charles Darwin's
Evolution Theory Stone Dead

Well not all of it - his core idea of survival of the fittest still survives unchallenged within science.

But his ideas of slow and steady vertical inheritance of slow and steady change has been dealt its deathblow in recent years.

The sudden existence of multi-antibiotic resistant bacteria in populations as isolated as uphill tribes in New Guinea, only a few years after all these various antibiotics were first manufactured by Man, couldn't mathematically be explained by
accidental small mutations accumulating over millions of years.

Ask any math major the odds that a bacteria in a human in uphill New Guinea, could by a very slow (10 to the minus nine rate of random DNA coding error, so called point mutations) process, randomly create the dozen genes needed to destroy four antibiotics first manufactured only 6 years earlier in London !

Talk about monkeys typing up all the works of Shakespeare....

No ,what happens is that some bacteria collected up all the various antibiotic-destroying genes floating out in the waters around them and re-packaged them in larger cassettes of bacterial resistance software - and then returned them to the waters for other bacteria to take up as one unit, if they really needed them , say in hospital or farm settings.

Collectively, bacteria already have all the genes to destroy any known antibiotic - or they can quickly mash up a variant to deal with a new variety.

But all this takes up precious energy - so only a few individuals, at any one time, holds an active copy of any particular method of destroying antibiotics.

It is all rather like a single planet-wide huge, multi-billion volume, free public library that does not exist in big government-owned buildings but in the homes of all humans.

Each human only has a few, but unique, selection of books, but because they freely share them without demanding copyright fees, collectively humans have access to a far bigger library than if they were selfish and didn't share their books.

Oh, and another thing - each human is both an author and a book reader - reading a lot of books before writing their own variant on the vast body of already existing thought.

What does this mean for us humans in crisis?

The habitually poor human being, having few assets to protect or to lose, are promiscuous in taking up new ideas and tools and adapting them in unexpectedly creative ways.

They 'mash-up' a variety of unrelated technologies, careless of the fact that their owners or creators don't want them mashed up that way.

In doing so, they come up with new takes on old ideas - some, a few,very few, turn out to be strokes of sheer unfettered genius - and help point the way ahead for a society in crisis.

And we are a definitely a society and a world community in profound crisis.

The depletion of natural resources, from the end of Cod to the beginnings of the downhill slope of Peak Oil, threatens both our cozy way of life and the fate of all Life on this Planet, through Global warming and habitat destruction.

Expressed in terms of economic 'business models' , this crisis can be described as 'the old business models are no longer working.'

The most K-selected amongst us - Conservative Parties , the Telcos and the record & movie labels - have responded in true K- fashion: they have drawn up their intellectual wagons in a circle and are decided to defend what they already have, rather than venture out into scary un-charted waters.

In copyright law terms, that means the K amongst us, the wise and the mighty, have sought and won longer and longer terms for the copyrights they already own, and also won the right to greatly restrict the creative mis-use of those copyrights by others.

And it is no surprise that it is the poor (the weak and the foolish r-selected) around the world who have led the way in mash-up copyright, from scratching, sampling to today's video mash-ups

We humans face a similar serious crisis to what bacteria face frequently and we need the same sort of solution - we need to loosen, not tighten, our copyright/patent/building code rules.

Unleash the Chiang Kai-Shek amongst the poor and small and remote parts of the world where the inhabitants are flexible and versatile by necessity.

My own region, the Maritimes, is small, poor and remote and are famous (infamous) for its rural citizens being masters-of-no-trades .

Maritimes are not paragons of 4-H agriculture , but rather of 4-F agriculture: farmin',fishin',forestin', and factoryin' .

They get by, they improvise.

When the crisis hits ,they'll get by.

But why wait till a crisis hits, with all its suffering, wars and misery ?

Loosen up our rules on house-building, on copyright and patents - let's see what emerges - it will benefit the 'suits' in Toronto as much as the fisherman down in Cape Sable.....

Friday, October 9, 2009

Janet Browne, Darwin's mega-volume biographer, to speak at Dal


While everyone is ignoring the 300th anniversary of Copyright (sigh !) we are all supposed to be guyed up to mark the 200th B-day of C. Darwin.

Yawn - I just don't like the guy.

Ironically, the reason why I do not like Charles is because of the tireless efforts of Janet Browne, who went way down deep in the dusty archives and came up with biographic gold on Mr Darwin.

Ironically, because I believe Professor Browne was and remains a big fan of Darwin, warts and all.

Her two volume mega-kilogram bookstops ( "Voyaging" and "Power of Place") reveal that Darwin thought nothing of stealing valuable documents from grieving widows or of slandering opponents, through the use of surrogates ,so Darwin could keep his reputation of high moral character.

Worse of all, in his brief autobiography, Darwin denied any credit to his doting father for helping Charles to claw his way to the top of the world of science.

Doted upon ? Spoiled is a better word.

Charles Darwin was given extremely expensive scientific equipment for his hobbies as a child - such as a microscope that would cost the annual income of a half dozen farm labourers for example.

Without all the support that his mega-millionaire father and wife (mega-millionaire in in 2010 dollars) gave him, Darwin would never had been credited with discovering evolution.

Then he goes and denies that his unique access to these and other scientific aids gave him any leg up over his poorer scientific competitors.

Ingrate ! Spoil your child and he'll bite your hand in thanks, I always say.

Anyway , Janet Browne speaks at Dal's Ondaatje Hall October 15th 8pm --- and I will be there.....

Wednesday, September 23, 2009

Oswald Avery's connection to Haldeman-Julius


It seems an unlikely connection, but there does exist a tenuous connection between two of our favorites here at the online edition of the Arcadian Recorder.

Oswald Avery's grandfather was publicly credited as having helped perfect the successful printing of tiny, light, complete, readable bibles on India Paper and thus helping to secure the fortunes of the hitherto hapless Oxford University Press.

Since OUP, as it is usually known in the book trade, is today one of the most valuable trademarks in the world, this is a story worth recalling.

OUP gained this rise to world prominence based on its exclusive hold on the secret knowledge required to make India paper - a incredibly thin, flexible, strong and yet opaque & non-yellowing paper made out of old hemp ropes and lots of lime.

It allowed you to pack in a million readable words (like the Bible) in a small, light but permanently readable book - perfect for shipping in mass quantities across the world on a very tight budget.

For Christian evangelicals determined to 'evangelize the world in one generation' it was - literally - a God-sent paper.

OUP quickly sold millions of its lightweight bibles, dictionaries and reference books based on the use of this paper.

Haldeman-Julius couldn't afford the price of this paper and expect to keep selling his 'little blue books' at the price of an American nickel shipped post-paid worldwide.

But his mind moved along the same lines of constantly seeking ways to 'mass-evangelize the world' at a reasonable price.

His book-making frugality matched and even exceeded those of his competitors in the world of Christian bible and tract makers.

I say 'competitors' because of course the personal dogma of Haldeman-Julius that drove him to be equally frugal in his printing methods was simply this: " There is no Christian God" !

Friday, September 18, 2009

Top-Down Genetics versus Mashup Genetics


'Must confess.

We never did like the term 'Horizontal Gene Transfer' , aka HGT ( sometimes otherwise known as LGT ,for Lateral Gene
Transfer).

In particular we always hated that 'transfer' bit.

The denotation is accurate enough, but its connotations conjure up entirely the wrong impression.

We'd bow in the direction of Dawson and call it HGT , Horizontal Gene Transformation.

For in fact the incoming bits of DNA disrupt - creatively - the existing fat and comfortable set of genes in the organism being invaded and the end result isn't some tidy orderly transfer of assets from one bank account to another, but more in the order of a micro-scale catastrophe.

There said it.

Catastrophe, cat-as-tro-phe - not neo-catastrophism, because we don't think it ever really went away - not out there in the real world and not out there in the real minds of many.

Only scientists and their fellow travelers consigned the word to a sudden death.

They said catastrophes rarely happen and when they do they are only local and short term - and soon we will be able to predict and prevent even these rare local events.

Catastrophes at the level of cells and microbes simply never happened.

But they do - we multi-celled creatures are the result of one such genetic mashup - when one sort of bacteria survived inside another type of bacteria to the point where it became part of the bacteria, inside its own cell walls and created the first multi-celled being .

Nine months later,more or less, you and us emerged.

There is no intellectual crime lower than seeking support for some or other human theory by claiming it merely reflects the laws of nature.

But...

But it is interesting to tease out the parallels for human creativity in the current moves to mashup old boring top down controlled copyrights to see what crawls out of the shell and the tremendous effects HGT has had in the past in mashing up stale boring old top down Vertical genetics to see what happens.

Penicillin , after all, was the result when a bacteria and a yeast decided to mashup their quite different DNAs....


Thursday, September 10, 2009

The 1940 Peace Bomb joins the 1800 Peace Mine...


In any other circumstances, pacifist Leo Szilard might have been best remembered as the inventor (along with fellow pacifist Albert Einstein) of the modern fridge.

Instead he joined some others (sometimes pacifist others) in working on a super weapon that would so frighten the planet's militarists that they would instantly sue for permanent world peace.

Unfortunately, it was agreed that the backward militarist mind would require a convincing demonstration project, before being convinced.

So in the end a few hundred thousand people ended up dead in radiation and fire, all for 'the greatest good of the greatest number' ---but universal peace still did not break out - far from it.

So poor Szilard is today primarily remembered for instigating the Manhattan Project rather than inventing the perfect fridge ....or the perfect peace.

By contrast, Robert Fulton, a fellow New York City area resident like Szilard, (albeit from a hundred and fifty years earlier ), is best known today for building the first commercial steam boat service in the world, between New York City and Albany.

But as H. Bruce Franklin points out in his ground-breaking book "War Stars" , Fulton had had his utopian pacifist weapon scheme as well.

This submarine and sea-mine system was designed to destroy the British navy, freeing the high seas for universal free trade and commerce and thus introducing an era of permanent world peace.

This was/is standard centuries-old Liberal dogma, still much spouted today.

Fulton's willingness to sink a few real ships (along with their real crews) is also right on par with all the many Liberal peace bomb efforts: in the utilitarianism-driven willingness to see a 'few' die (unwillingly and unasked) for the greater good of the greater number.

Between Fulton and Szilard, New York has thrown up a number of Liberal pacifist and their peace weapons - perhaps most notably that shy pacifist Carl Norden.... and his precision WW II bombsight of the same name.

All these plans start off as efforts to design a totally new advance on weapon systems.

But these superweapons are not for profitably continuing sales in continuous wars.

Rather they are to 'demonstrate' their horrific effects just once and then usher in world peace forever.

All of them have a scope and gravitas and a vision about them that seems perfectly cut to fit Manhattan's taste in grandness-for-the-sake-of-grandness, thus becoming 'the Empire State Building of New York intellectual conceits'.....

Wednesday, September 9, 2009

Oswald Avery : unknown and famous for the wrong things...


It is the tragedy of Halifax Nova Scotia born Oswald Avery that he is famous for a study he didn't really believe in (and opposed for years) and he is unknown for his lifework, which today saves millions of childrens' lives around the world each year.

Oswald Avery is today known as 'The Father of Molecular Biology' , which should tip us off right from the start.

Scientists are never more manipulative and intellectually dishonest than when they are fabricating the history of the "Father" (never the "Mother" or "parents") of their particular branch of science.

Avery is no exception. In this case, we know this to be so, because the person who created the myth of Avery (Joshua Lederberg) said so: he intended to 'do a Mendel on Avery'.

Gregor Medel did wonderful pioneering work , but his credentials for being considered the father of any science are widely regarded today as spurious - and he would be the first to say so loudly if he came back today.

As would Avery regarding his alleged founding role in molecular biology - to his credit, he never claimed much for his work in this field while he was alive - and he lived for 10 years after his 'big' discovery.

But in the saving-the-lives-of-millions-of-innocent-baby-children world, the world of conjugate vaccines, Avery is a GIANT - or should be.

He certainly is to the researchers in that field.

But he is merely 'the key individual' in an effort that spanned a century and included every continent,thousands of researchers and hundreds of millions of dollars.

It is a story far too vast and far too complicated for popular science reporting to credit to any one medical super hero and one shining experimental result: no Pasteur or Jonas Salk here.

Instead Avery is praised for one 'seminal-paper-that-was-ignored-at-the-time' --- which rather implies an intellectual oxymoron and suggests the difficulty in crediting him as the Father of anything .

That paper was published in February 1944 but had its formal beginnings with experiments that began on October 22nd 1940 on Manhattan Island, that tiny island not far off the American coast.

Ah yes ! October 1940 : menses mirabilis indeed.

It is almost as if May 1940, certainly one of the most 'menses horribilis' in all of Western Civilization, (followed by the August to September 1940 aborted invasion of England : half horribilis half mirabilis), seemed to have drawn out extraordinary efforts from various North American scientists deeply emotionally affected by the events in Europe but too old to be called to actively take up a rifle.

Because one of the things those three extraordinary laboratory efforts in October 1940 have in common is their sheer physicality - scaled up to pilot plant size before table top work had even started; dirty, tiring, dangerous work.

Literally, not just figuratively, fighting for results in the trenches of science.

So, if in October 2010, we mark the 70th anniversary of the start of the financial recognition for (a) George Laurence's efforts to build an atomic pile, and (b) Henry Dawson's start in his efforts to cure SBE with natural penicillin injections, we might as well add (c) the formal start of Oswald Avery and Colin MacLeod's efforts to determine the chemical nature of Henry Dawson's Transforming Principle - proving it to be DNA.

Did we say 'North American scientists' ??

Let it stand.

We all know that we here at the Arcadian Recorder also mean 'Nova Scotian-born scientists', but let that remain our little secret.....

Tuesday, September 8, 2009

The Manhattan Pilot : Harlem Shuffled


What could seem more innocent than a project initiated by pacifists and an airplane named after someone's mother?

And what could seem more threatening than a project invigorated by a group of veterans of the frontline trenches and a heavy bomber ominously named 'The B-a-a-d Penny' ?

The cliches of innocence and harm align neatly enough in Hollywood movies but in the real world, events often show themselves to be a great deal more paradoxical.

In 1999, a survey by Newseum and USA Weekend of 36,000 American men and women revealed that they thought the top news story of the entire twentieth century involved a little boy and a baby girl and took place in an eighty acre area on a tiny island not far off the American coast.

In that tiny eighty acre area, the pacifists and the frontline vets worked on their projects almost within sight of each other, albeit while existing in totally different moral universes.

And as every good eighty acres should, this story involved a mule.

His name was Henry Dawson.

This is not his biography, but it is his story....

Tuesday, August 25, 2009

VEGEMITE also had its hour ; one far fierce hour and sweet



Yellow Snow Bad; Yellow Uisce Beatha Good

It is no secret that Irishmen like their drink, even ( or perhaps, particularly) in wartime.

For a real Irishman likes nothing better than defying straitlaced authorites who think sugar and alcohol has higher uses in wartime than to just use in beverages - such as using them to make more and stronger explosive materials.

So in November 1943, it probably won't seem that unusual to see a feisty Irish-Australian named Jim Duhig sprinkle some yeast-like material over a vat of water and molasses and put it in a cool dark place for ten days.

We say yeast-like because yeast extract was unavailable in wartime Brisbane (Queensland) Australia.

Jim did what any quick thinking Aussie would do - he reached for that all purpose substitute, Vegemite in .3% solution, because after all, he did come from the land down under, where beer flows and strong men chunder.

Also not unusual was his decision to strain the resulting golden colored liquid at the bottom of the vat through a piece of cheesecloth and put it into bottles.

But what he did next might surprise you : he drew some of that golden liquor out in a big needle and stuck it - again and again - into a dying woman.

He saved her life with this golden uisce beatha and saved four other dying patients' lives with it as well, in addition to successfully treating another two dozen less severe infections with his brew.

Duhig's technique, as crude as it seems, is about as high tech as antibiotic science & industry ever has to get, if its only interest is in saving lives.

But it isn't and Jim Duhig's heroic actions came 15 years after Penicillin's initial discovery.

Millions would have lived ( longer - for we all must die at some time) if Alexander Fleming had felt in 1928 as Dr Duhig felt in 1943.

But he didn't and neither would have Dr Duhig in 1928.

It took someone else, someone far bolder than Fleming or Dunhig or Florey, to kickstart the radical-at-the-time idea that injecting natural penicillin into a patient's bloodstream was the best possible treatment of most life-threatening systemic bacterial infections.

That bold idea was first enacted upon on a tiny island, not far off the American coast, a few years earlier.....

Jim Duhig was indeed very Irish - his uncle was the archbishop of Queensland - but in real life he didn't brew liquor - or even drink - he was the head of a prohibitionist society.

But he did brew penicillin---- rather than see some patients die needlessly while waiting for Big Pharma to get its act together to do in decades what Jim had done in weeks !

Life is much stranger than fiction.



Saturday, August 22, 2009

70th Anniversary of 'the little $6,000 that grew'


In February 2010, most of the world will not celebrate the 70th anniversary of the start of the Manhattan Project.

Nor should they.

But they should mark it, and pause to reflect on its continuing consequences for us here today.

For 1940 was truly an Annus Mirabillis , and only partly because it marked the start of the development of the world's biggest life-taker.

Because 1940 was also crucial in the development of the world's smallest life-saver .

And aren't these two things the Alpha and the Omega of a continuing human existence in this universe?

During that February almost seventy years ago, two lead investigators at Columbia University in Manhattan were given $6,000 in federal tax dollars to look into the possibility of developing an atomic 'boiler' - which is to say, given money to develop an engine, not a bomb.

But the money came from orders of the president himself and FDR knew the project, if fully successful, would lead to investigating the building of an atomic bomb, to be held in reserve against the possibility the Nazis were already trying to build - and use - one.

Seventy years on, the six thousand dollars has become, for the American taxpayers alone, six trillion dollars and counting.

Laying blame for the current American debt crisis ? February 1940 is as good a place as any to start - that six trillion dollars would sure erase a lot of America's public and private debt worries.

If the American nuclear bomb arsenal of today ever gets used in a shooting match, the cost in lives would be six billion plus - and probably no one left to do the counting.

The costs of this the best known of Manhattan's wartime projects, in terms of the tarnishing of America's image abroad, is impossible to calculate.

"THE BUCK STARTS HERE"
The desk of the president is famously thought of as the place where the sign reads "the buck stops here".

But this project was highly unusual, in that it can be more truly said of the Manhattan Project, that "the buck started here", right at the president's desk.

As its political and financial father, FDR 'knew' about the start of the building of the world's biggest life-taker long before almost anyone else on the planet.

Not so with the start of the other Manhattan-based project , the one to finally start saving lives with the world's smallest life-saver, twelve years after its initial discovery.

FDR first learned of this life-saving substance at the exact same time that the rest of the world did , by opening his paper and reading a highly dramatic news story, one morning in mid-August 1943, almost three years after the life-saving project's obscure beginnings.

Perhaps the delay in the president learning of this life-saver is best explained by the fact that this project's lead investigator, also at Columbia University, never asked for any federal government grant or presidential 'seal of approval' - and in fact never sought a grant from anyone.

Still , his work never added a cent to the federal debt and his legacy continues to add lustre to the American image abroad.

Few people around the world, including those terrorists who harbor nothing but ill will towards Manhattan Island, do not have a family member or friend whose life was spared, thanks to the kick-starting efforts of this Manhattan Island life saver.

His project's 70th anniversary also comes up next year, in September 2010.

Perhaps this other Manhattan Project also needs a moment from us, to reflect on the changes it has brought into our world.

In this case, changes much for the better....

Wednesday, August 19, 2009

the Oxymoronic 'doomed' Megalopolis


It is always painful , here at the Arcadian Recorder anyway, to see authors writing of a 'doomed' Megalopolis.

This is akin to hearing people talk about the 'dumb version' of George W Bush.

Blame the Japanese - manga, anime and all.

Inherent in the history of, and hence in the connotations of , the original Megalopolis is the fact that the glorious future foreseen for it by its founders all came to not.

Once expected to be the biggest city on earth, it relatively quickly ended up as a deserted and unpopulated dot on a rural backroad.

It is hard to imagine a failure more total than that.

A 'Mega' flop in fact.

In the days when knowing Latin and Greek history was part of every educated person's upbringing, this fact was well known.

This perhaps is the reason we didn't see any past city fathers, even those with the most oversized egos, daring to call their large cities 'megacities' or speaking of the residents of their surrounding suburbs as living in 'megaland' .

The more modest, but more neutral, term 'metro' ( meaning 'mother' !) suits these 'fathers' just fine !

Tuesday, August 18, 2009

September 7th 1943: Madison Ave lays egg


In September 1943, Madison Avenue's advertising agencies (America's slavering class) were all talking about the newest addition to the wonder drug family, Sulfa-Thiazole Band-Aids.

Which was unfortunate; sad really.

Because all of their clients' customers were talking about another wonder drug, Penicillin.

No contest really.

On one hand, ads offering up band-aid solutions , on the other hand, the front pages of those same newspapers busy telling tales of a young girl being plucked back from the brink of death after a dramatic cross country flight by a heavy bomber.

The B-24 heavy bomber, aptly called a Liberator , ditched its normal wartime payload of 8000 pounds worth of bombs to fly in 8 grams of this 'pen-i-cil-lin' livesaver.

What a goldmine in 'earned media' for that lucky drug company !

But search as the Mad Men may, it seemed no New York agency, large or small, had that valuable account.

FASTEST EVER ' PHENOMENON ' ?

No major phenomenon , not Elvis not TV not VCRs, ever caught on worldwide as fast as Penicillin did.

This, despite a world tied up in the all enveloping censorship of Total War.

One looks to something minor like 1958's hula hoops craze but even this fad only penetrated to some of the people in some of the countries of the world.

Penicillin was virtually unknown worldwide on August 10th 1943 (more accurately: uninteresting to the few that had heard about it) .

But by September 10th 1943, much of the world had heard about it, wanted to know more about it and above all, wanted it - yesterday.

Meanwhile, that week Johnson and Johnson was rolling out full page full color ads in all the major consumer media touting its
new sulfa-saturated Band-Aids.

One of the versions of the ad campaign has remained a popular item on E Bay, and other 'collectable' sites, to this day.

It features a painting of five incredibly cute tow-headed children playing at 'war'.

It sounds like it should repulse most of its potential customers, the mothers of America, but it doesn't seem to - this is the power of Madison Avenue at its most seductive.

The only girl among the five is the focal point and the star; she is dressed up as a nurse, and is carefully applying a Band-Aid to the upper arm of a boy soldier with a wooden gun, complete with fixed, wooden, bayonet.

He is grimacing bravely as the Band-Aid approaches.

Another boy, in a formfitting leather and wool football helmet/ pilot's helmet (complete with goggles jauntily astride on top) is staring round eyed at the approaching Band-Aid.

Meanwhile a child with a saucepan for a helmet ( and as a result looking alarming 'Kraut-like' is coming through an obstacle course made up of open-ended rain barrels, armed with his gun and bayonet.

Thankfully, the final child looks and acts like a child, coming up along rapidly as possible so he doesn't miss whatever might be going on - but even he must scramble over a wooden barrier that looks exactly like the similar wooden wall/barrier seen in every photo essay on basic training since the First World War.

The cut line for the ad informs Moms everywhere that they can finally get some of the same Sulfa medication as used in Front Line Hospitals to save lives ( perhaps even their husband's life).

It has just been added to the Band-Aids they apply for their Home Front child's minor cuts and scrapes, to give the kids the same battlefront strength protection that Dad is getting.

A much lesser know version of this ad campaign lays out its theme in a much more heavy handed manner - probably why it hasn't survived in the folk memory.

A Mother (definitely not a 'Mom') Band-Aids her worried looking pre-teen son in the right frame.

In the left frame , grim-faced (and dirty-faced) GIs and medics apply Sulfa-Thiazole to a wounded soldier in a stretcher, not far from a Pacific War battle scene.

The posing and expressions of the wounded man, the onlooking soldiers and the medic makes it appear as if the medic is applying the Last Rites, rather than saving the man's life !

The cutline praise Thiazole as one of the famous Sulfas, 'the drugs everybody's talking about' .

If the ad had come out even a month earlier, this would be definitely true.

Most doctors hadn't even laid their eyes upon a sample of the original sulfa drug until about seven years earlier and each year had brought a major new addition to the sulfa family , curing more and more hitherto unreachable bacteria types.

All were synthetics, totally man-made and the chemists kept coming up with new creations - almost 5000 registered new variants in America alone between 1936 and 1944.

It seemed like an Oil Well that would never run dry.

And then in the space of a month, it was bang-bang, dead.

Worldwide.

Because even behind the Nazi held lines, the occupied peoples were hearing about Penicillin in terms that made it sound like a literal, not just figurative, Miracle.

Madison Avenue's stock in trade is figurative Miracles but not even it was prepared for a real Miracle it seems...

Monday, August 17, 2009

On the May & Baker factory floor, the magic bullet of M&B 693 was decidedly low tech


Science journalism and Chemistry Industry advertising (often hard to tell apart in the 1930s) saw the new Sulfa Drugs as the latest and most glamorous product to roll out of the cornucopia of the synthetic arcadia.

But as John Lesch describes in his account of how the British drug firm May & Baker developed its famous M&B693 (the sulfa drug that saved Churchill's life at the height of World War II) the view from the factory floor was distinctly low tech.

A dusty bottle of a rarely used chemical compound, made up for an ex-employee who never used it, but retained by the research lab of a large drug firm because, well, its the Great Depression and money is too tight to lightly throw anything out.

Experimental Chemistry Theory insisted there is absolutely no point in wasting effort in trying the contents of that old
chemical bottle in synthesising a potentially useful analogue from the original German sulfa compound.

Fortunately, an older tradition (in medicine they call this the 'hands on' or clinical approach) said "try everything" .

Unexpectedly ,and thankfully, the unusual new compound showed some promise in the chemical lab.

But the next stage would be to try it on deliberately-infected mice in another type of lab.

But this lab had none of the usual mice (infected with strep bacteria) -- money was tight in the Depression remember ?---
so a harried assistant, trying to fill in for his boss while he was away, tested the compound instead on mice inflected with the bacteria that gives us the worst kinds of pneumonia.

Nothing had ever killed these bacteria reliably and almost everything possible had been tried on them since 1919 and the pandemic of Spanish Flu.

(Most of the Spanish Flu's 50 million deaths worldwide were actually caused by pneumonia -- reason enough to research it more thoroughly than any other virulent agent had been to date.)

Once again, trying the unexpected and the unscientific paid off - this new sulfa killed the most dangerous of the pneumonia types.

This would, if confirmed, be headline news worldwide and would push May & Baker into the front rank of world drug firms.

But for now, back to Depression realities.

A number of intermediate chemicals had to be made in quantity on the way to making the actual sulfa.

Various stratagems were employed as the factory hands struggled to break up recalcitrant chunks of an important intermediate into a coarse powder, without blowing up themselves and their building.

Their delicate lab-grade tools of high precision?

A hammer and chisel !

Then a lot of ordinary mortars and pestles were filled with the crude powder and it was slowly,painfully, hand-ground down to a sufficiently fineness.

May and Baker, despite being a large, diversified , long standing British drug house , had no vacuum still and so its first sulfa 693 had to be made up in one or two litre flasks, so to make that first batch of one kilogram took two months of hard unrelenting effort on behalf of the entire team.

Still,a little of that very first batch in early February 1938, saved the life of a Norfolk farm labourer who was given up for dead because of his seemingly non-responsive lobar pneumonia.

A decidedly better result that the much better known first British effort, in early February 1941, to use penicillin to save the life of a policeman !

Pneumonia - the dreaded 'Captain of the Forces of Death' - had a cure !

But Lesch's detailed account of the development of M&B693 bears only the most fleeting acquaintance with the usual starry-eyed account provided to the public by Thirties media accounts...

On the May & Baker factory floor, the magic bullet of M&B 693 was decidedly low tech


Science journalism and Chemistry Industry advertising (often hard to tell apart in the 1930s) saw the new Sulfa Drugs as the latest and most glamorous product to roll out of the cornucopia of the synthetic arcadia.

But as John Lesch describes in his account of how the British drug firm May & Baker developed its famous M&B693 (the sulfa drug that saved Churchill's life at the height of World War II) the view from the factory floor was distinctly low tech.

A dusty bottle of a rarely used chemical compound, made up for an ex-employee who never used it, but retained by the research lab of a large drug firm because, well, its the Great Depression and money is too tight to lightly throw anything out.

Experimental Chemistry Theory insisted there is absolutely no point in wasting effort in trying the contents of that old
chemical bottle in synthesising a potentially useful analogue from the original German sulfa compound.

Fortunately, an older tradition (in medicine they call this the 'hands on' or clinical approach) said "try everything" .

Unexpectedly ,and thankfully, the unusual new compound showed some promise in the chemical lab.

But the next stage would be to try it on deliberately-infected mice in another type of lab.

But this lab had none of the usual mice (infected with strep bacteria) -- money was tight in the Depression remember ?---
so a harried assistant, trying to fill in for his boss while he was away, tested the compound instead on mice inflected with the bacteria that gives us the worst kinds of pneumonia.

Nothing had ever killed these bacteria reliably and almost everything possible had been tried on them since 1919 and the pandemic of Spanish Flu.

(Most of the Spanish Flu's 50 million deaths worldwide were actually caused by pneumonia -- reason enough to research it more thoroughly than any other virulent agent had been to date.)

Once again, trying the unexpected and the unscientific paid off - this new sulfa killed the most dangerous of the pneumonia types.

This would, if confirmed, be headline news worldwide and would push May & Baker into the front rank of world drug firms.

But for now, back to Depression realities.

A number of intermediate chemicals had to be made in quantity on the way to making the actual sulfa.

Various stratagems were employed as the factory hands struggled to break up recalcitrant chunks of an important intermediate into a coarse powder, without blowing up themselves and their building.

Their delicate lab-grade tools of high precision?

A hammer and chisel !

Then a lot of ordinary mortars and pestles were filled with the crude powder and it was slowly,painfully, hand-ground down to a sufficiently fineness.

May and Baker, despite being a large, diversified , long standing British drug house , had no vacuum still and so its first sulfa 693 had to be made up in one or two litre flasks, so to make that first batch of one kilogram took two months of hard unrelenting effort on behalf of the entire team.

Still,a little of that very first batch in early February 1938, saved the life of a Norfolk farm labourer who was given up for dead because of his seemingly non-responsive lobar pneumonia.

A decidedly better result that the much better known first British effort, in early February 1941, to use penicillin to save the life of a policeman !

Pneumonia - the dreaded 'Captain of the Forces of Death' - had a cure !

But Lesch's detailed account of the development of M&B693 bears only the most fleeting acquaintance with the usual starry-eyed account provided to the public by Thirties media accounts...