Fleming, in this extremely famous article, defines his "penicillin" as consisting of one or more soluble solid active ingredients in a liquid nutritional broth, no more and no less.
He makes it clear that "penicillin" is merely a useful shorthand for that cumbersome longer phrase.
He never once uses the word impurities or impure or crude: to him his active ingredient is perhaps ALL of the soluble solids left behind when the water is evaporated .