Penicillin : biologic 1929-1939 , chemotherapeutic 1939-1949

In 1944, Frank M Berger ( later creator of the post-war drug Miltown but then just a worker in a local municipal public health lab in the remotes of northern England)  came up with an unique way of making and using penicillin.

On second thoughts, his method might well have been done first by Alexander Fleming's Wright-Fleming vaccine institute and their pharmaceutical distributor Parke-Davis about 15 years earlier : Penicillin the Biologic.

On further further reflection : should have been done first by Alec Fleming.